Melancon, Bruce J.: search on Z-Library

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1

Measurement characteristics of the finding embedded figures test

Janet G. Melancon, Bruce Thompson

Journal:

Psychology in the Schools

Year:

1989

Language:

english

File:

PDF, 709 KB

english, 1989

2

Maximizing Test Reliability by Stepwise Variable Deletion: A Case Study with the Finding Embedded Figures Test

Melancon, Janet G., Thompson, Bruce

Journal:

Perceptual and Motor Skills

Year:

1990

Language:

english

File:

PDF, 450 KB

english, 1990

3

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

Bruce J. Melancon, Rocco D. Gogliotti, James C. Tarr, Sam A. Saleh, Brian A. Chauder, Evan P. Lebois, Hyekyung P. Cho, Thomas J. Utley, Douglas J. Sheffler, Thomas M. Bridges, Ryan D. Morrison, J. Sco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.81 MB

english, 2012

4

Optimization of M 4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

Melancon, Bruce J., Wood, Michael R., Noetzel, Meredith J., Nance, Kellie D., Engelberg, Eileen M., Han, Changho, Lamsal, Atin, Chang, Sichen, Cho, Hyekyung P., Byers, Frank W., Bubser, Michael, Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 803 KB

english, 2017

5

Selected Correlates of Computer Arcade Game Play

Melancon, Janet G., Thompson, Bruce

Journal:

Perceptual and Motor Skills

Year:

1985

Language:

english

File:

PDF, 261 KB

english, 1985

6

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2019

File:

PDF, 94 KB

2019

7

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 94 KB

2020

8

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.00 MB

english, 2013

9

A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors

Pyburn, Tasia M., Bensing, Barbara A., Xiong, Yan Q., Melancon, Bruce J., Tomasiak, Thomas M., Ward, Nicholas J., Yankovskaya, Victoria, Oliver, Kevin M., Cecchini, Gary, Sulikowski, Gary A., Tyska, M

Journal:

Year:

2011

Language:

english

File:

PDF, 2.31 MB

english, 2011

10

Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN Probe ML012

Bruce J. Melancon, Alexander P. Lamers, Thomas M. Bridges, Gary A. Sulikowski, Thomas J. Utley, Douglas J. Sheffler, Meredith J. Noetzel, Ryan D. Morrison, J. Scott Daniels, Colleen M. Niswender, Carr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.09 MB

english, 2012

11

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Miyake, Yasuyuki, Keusch, Jeremy J, Wang, Longlong, Saito, Makoto, Hess, Daniel, Wang, Xiaoning, Melancon, Bruce J, Helquist, Paul, Gut, Heinz, Matthias, Patrick

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.32 MB

english, 2016

12

Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Poslusney, Michael S., Salovich, James M., Wood, Michael R., Melancon, Bruce J., Bollinger, Katrina A., Luscombe, Vincent B., Rodriguez, Alice L., Engers, Darren W., Bridges, Thomas M., Niswender, Col

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 522 KB

english, 2018

13

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Wen, Wandong, Young, Summer E., Duvernay, Matthew T., Schulte, Michael L., Nance, Kellie D., Melancon, Bruce J., Engers, Julie, Locuson, Charles W., Wood, Michael R., Daniels, J. Scott, Wu, Wenjun, Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 3.61 MB

english, 2014

14

Chromophore Formation in Resorcinarene Solutions and the Visual Detection of Mono- and Oligosaccharides

He, Ming, Johnson, Rolanda J., Escobedo, Jorge O., Beck, Patricia A., Kim, Kyu Kwang, St. Luce, Nadia N., Davis, Claude J., Lewis, Patrick T., Fronczek, Frank R., Melancon, Bruce J., Mrse, Anthony A.,

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 248 KB

english, 2002

15

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

Xiang, Zixiu, Thompson, Analisa D., Brogan, John T., Schulte, Michael L., Melancon, Bruce J., Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, B

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 2.89 MB

english, 2011

16

Discovery of tricyclic triazolo- and imidazopyridine lactams as M1 positive allosteric modulators (PAMs)

Engers, Julie L, Bender, Aaron M., Kalbfleisch, Jacob J, Cho, Hyekyung P., Ligenfelter, Kaelyn S, Luscombe, Vincent B, Han, Changho, Melancon, Bruce, Blobaum, Anna L., Dickerson, Jonathan W, Rook, Jer

Journal:

ACS Chemical Neuroscience

Year:

2018

Language:

english

File:

PDF, 1.12 MB

english, 2018

17

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

Poslusney, Michael S., Melancon, Bruce J., Gentry, Patrick R., Sheffler, Douglas J., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

18

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease

Melancon, Bruce J., Tarr, James C., Panarese, Joseph D., Wood, Michael R., Lindsley, Craig W.

Journal:

Drug Discovery Today

Year:

2013

Language:

english

File:

PDF, 1.63 MB

english, 2013

19

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs

Davis, Dexter C., Bungard, Joseph D., Chang, Sichen, Rodriguez, Alice L., Blobaum, Annie L., Boutaud, Olivier, Melancon, Bruce J., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2021

File:

PDF, 569 KB

2021

20

Evaluating cytochrome P450 in lesser scaup (Aythya affinis) and tree swallow (Tachycineta bicolor) by monooxygenase activity and immunohistochemistry: Possible nonlethal assessment by skin immunohistochemistry

Mark J. Melancon, Amy L. Kutay, Bruce R. Woodin, John J. Stegeman

Journal:

Environmental Toxicology and Chemistry

Year:

2006

Language:

english

File:

PDF, 429 KB

english, 2006

21

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 93 KB

2020

22

In the July 2017 Issue of ASSAY …

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2017

Language:

english

File:

PDF, 45 KB

english, 2017

23

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 93 KB

2020

24

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Byun, Nellie E, Grannan, Michael, Bubser, Michael, Barry, Robert L, Thompson, Analisa, Rosanelli, John, Gowrishankar, Raajaram, Kelm, Nathaniel D, Damon, Stephen, Bridges, Thomas M, Melancon, Bruce J,

Journal:

Neuropsychopharmacology

Year:

2014

Language:

english

File:

PDF, 1012 KB

english, 2014

25

Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS): High-Resolution Physical and Transcript Map of the Candidate Region in Chromosome Region 13q11

James C. Engert, Carole Doré, Jocelyne Mercier, Bing Ge, Christine Bétard, John D. Rioux, Carolyn Owen, Pierre Bérubé, Keri Devon, Bruce Birren, Serge B. Melançon, Kenneth Morgan, Thomas J. Hudson, An

Journal:

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

26

Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2−C3 Double Bond Geometry

Bachmann, Brian O., McNees, Ruth, Melancon, Bruce J., Ghidu, Victor P., Clark, Rachel, Crews, Brenda C., DeGuire, Sean M., Marnett, Lawrence J., Sulikowski, Gary A.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 295 KB

english, 2010

27

Progress toward the Total Synthesis of Lucentamycin A: Total Synthesis and Biological Evaluation of 8- epi -Lucentamycin A

Daniels, R. Nathan, Melancon, Bruce J., Wang, Emily A., Crews, Brenda C., Marnett, Lawrence J., Sulikowski, Gary A., Lindsley, Craig W.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 1.07 MB

english, 2009

28

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 95 KB

2020

29

A concise Diels-Alder strategy leading to congeners of the ABC ring system of the marine alkaloid ‘upenamide

Wenzler, Marta E., Melancon, Bruce J., Sulikowski, Gary A.

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 426 KB

english, 2016

30

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Melancon, Bruce J., Hopkins, Corey R., Wood, Michael R., Emmitte, Kyle A., Niswender, Colleen M., Christopoulos, Arthur, Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 811 KB

english, 2012

31

A Microplate-Based Assay for Identifying Small Molecules that Bind a Specific Intersubunit Interface Within the Assembled HIV-1 Capsid

Halambage, Upul D., Wong, Jason P., Melancon, Bruce J., Lindsley, Craig W., Aiken, Christopher

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 799 KB

english, 2015

32

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Wood, Michael R., Noetzel, Meredith J., Engers, Julie L., Bollinger, Katrina A., Melancon, Bruce J., Tarr, James C., Han, Changho, West, Mary, Gregro, Alison R., Lamsal, Atin, Chang, Sichen, Ajmera, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 309 KB

english, 2016

33

Corrigendum to “Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]

Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Lamsal, Atin, Luscombe, Vincent B., Rodriguez, Alice L., Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Engers, Darren W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 119 KB

english, 2018

34

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 94 KB

2020

35

Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule

Melancon, Bruce J., Poslusney, Michael S., Gentry, Patrick R., Tarr, James C., Sheffler, Douglas J., Mattmann, Margrith E., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

36

Correction: A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors

Pyburn, Tasia M., Bensing, Barbara A., Xiong, Yan Q., Melancon, Bruce J., Tomasiak, Thomas M., Ward, Nicholas J., Yankovskaya, Victoria, Oliver, Kevin M., Cecchini, Gary, Sulikowski, Gary A., Tyska, M

Journal:

Year:

2012

File:

PDF, 7 KB

2012

37

Biomonitoring environmental contamination with pipping black-crowned night heron embryos: Induction of cytochrome P450

Barnett A. Rattner, Mark J. Melancon, Thomas W. Custer, Roger L. Hothem, Kirke A. King, Leonard J. Lecaptain, James W. Spann, Bruce R. Woodin, John J. Stegeman

Journal:

Environmental Toxicology and Chemistry

Year:

1993

Language:

english

File:

PDF, 1009 KB

english, 1993

38

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

Bruce J. Melancon, Thomas J. Utley, Christian Sevel, Margrith E. Mattmann, Yiu-Yin Cheung, Thomas M. Bridges, Ryan D. Morrison, Douglas J. Sheffler, Colleen M. Niswender, J. Scott Daniels, P. Jeffrey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 4.06 MB

english, 2012

39

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 2.20 MB

english, 2017

40

Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Lamsal, Atin, Luscombe, Vincent B., Rodriguez, Alice L., Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Engers, Darren W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 365 KB

english, 2017

41

Changes on the Horizon for Drug Repurposing, Rescue, and Repositioning at ASSAY

Melancon, Bruce J., Mucke, Hermann A. M.

Journal:

Assay and Drug Development Technologies

Year:

2018

Language:

english

File:

PDF, 41 KB

english, 2018

42

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

Evan P. Lebois, Gregory J. Digby, Douglas J. Sheffler, Bruce J. Melancon, James C. Tarr, Hyekyung P. Cho, Nicole R. Miller, Ryan Morrison, Thomas M. Bridges, Zixiu Xiang, J. Scott Daniels, Michael R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

43

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2019

Language:

english

File:

PDF, 94 KB

english, 2019

44

Discovery of VU0467485/AZ13713945: An M 4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Ch

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 679 KB

english, 2017

45

4040 Investigation of a Series of 1,4-diaryl-pyrazolo-pyridinones as Anti-Leishmanial Agents

Corman, Hannah Noel, Shoue, Douglas A., Melancon, Bruce J., McDowell, Mary Ann

Journal:

Journal of Clinical and Translational Science

Year:

2020

File:

PDF, 49 KB

2020

46

Moving Forward with ASSAY

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2017

Language:

english

File:

PDF, 39 KB

english, 2017

47

Competitive Cationic Pathways and the Asymmetric Synthesis of Aryl-Substituted Cyclopropanes

Melancon, Bruce J., Perl, Nicholas R., Taylor, Richard E.

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 75 KB

english, 2007

48

The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor

Kaur, Jatinder, Bhardwaj, Atul, Melancon, Bruce J., Blagg, Brian S. J.

Journal:

Synthetic Communications

Year:

2019

Language:

english

File:

PDF, 1.19 MB

english, 2019

49

VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate

Engers, Darren W., Melancon, Bruce J., Gregro, Allison R., Bertron, Jeanette L., Bollinger, Sean R., Felts, Andrew S., Konkol, Leah C., Wood, Michael R., Bollinger, Katrina A., Luscombe, Vincent B., R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 831 KB

english, 2019

50

Call for Papers: ASSAY and Drug Development Technologies

Melancon, Bruce

Journal:

Assay and Drug Development Technologies

Year:

2020

File:

PDF, 94 KB

2020

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